Multimodal pain management in the perioperative setting is rapidly evolving with novel non-opioid therapies poised to transform clinical care. Advancements in targeted approaches and delivery methods for acute surgical pain are expanding options beyond traditional opioid therapies, offering anesthesiologists and their teams new strategies to optimize patient care. Join us in person or virtually at ANESTHESIOLOGY 2025 for an engaging symposium led by two anesthesiologist experts in pain medicine. This session will explore the role of emerging non-opioid therapies, review the latest clinical evidence, and discuss clinical integration of novel therapies into personalized pain management plans.